An ill-defined region—because it was never a political unit—in the north-west corner of the Roman province of Asia (the Asian part of modern Turkey).
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Mysia is mentioned in the NT, twice only (Acts 16:7-8), in the context of Paul's Second Missionary Journey. Having travelled through the province to encourage the churches that they had founded on their previous journey, and delivering to them the important decision of the Jerusalem Council, Paul and his companions
"having been kept by the Holy Spirit from preaching the word in the province of Asia . . . came to the border of Mysia, they tried to enter Bithynia, but the Spirit of Jesus would not allow them to. So they passed by Mysia and went down to Troas. During the night Paul had a vision of a man of Macedonia standing and begging him, "Come over to Macedonia and help us." After Paul had seen the vision, we got ready at once to leave for Macedonia, concluding that God had called us to preach the gospel to them. From Troas we put out to sea and sailed straight for Samothrace, and the next day on to Neapolis. From there we traveled to Philippi, a Roman colony and the leading city of that district of Macedonia" (Acts 16:6-12).
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