The name traditionally given to Paul's evangelistic venture narrated in Acts 18:23-21:16, and is generally dated 53-57 AD. This journey is unique in that while it began as the earlier ones did from Antioch it would end with Paul in Jerusalem.
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The highlight of this journey was Paul's near-two-year stay in the city of Ephesus, where his ministry in the end turned out so spectacularly successful, it caused a riotous backlash (Acts 19). When things finally quieted down, Paul left for Macedonia and Greece, strengthening and encouraging the churches already planted there before they set back home headed for Jerusalem. On the way there they stopped at Caesarea where a prophet named Agabus took hold of Paul's belt and tied his hands and feet with it, foretelling that "The Holy Spirit says, 'In this way the Jews of Jerusalem will bind the owner of this belt and will hand him over to the Gentiles'" (Acts 21:11). When those with him pleaded with him not to go up to Jerusalem, but Paul would have it no other way, "Why are you weeping and breaking my heart? I am ready not only to be bound, but also to die in Jerusalem for the name of the Lord Jesus" (v13). Thus minded Paul journeyed on to his destination-in-chains.
You may also wish to see First Missionary Journey | Second Missionary Journey
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